Craig W Lindsley Selected Research

Dizocilpine Maleate (Dizocilpine)

1/2022	mGlu1-mediated restoration of prefrontal cortex inhibitory signaling reverses social and cognitive deficits in an NMDA hypofunction model in mice.
1/2018	Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154.
3/2016	State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects.

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Craig W Lindsley Research Topics

Disease

62	Schizophrenia (Dementia Praecox) 12/2023 - 11/2004
28	Neoplasms (Cancer) 01/2020 - 01/2005
26	Parkinson Disease (Parkinson's Disease) 11/2023 - 07/2005
21	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 10/2008
12	Catalepsy 01/2021 - 10/2008
6	Substance-Related Disorders (Drug Abuse) 01/2023 - 01/2013
6	Seizures (Absence Seizure) 01/2019 - 10/2008
5	Cognitive Dysfunction 01/2023 - 05/2013
5	Neurodevelopmental Disorders 01/2022 - 01/2017
5	Infections 12/2018 - 09/2014
5	Neurobehavioral Manifestations 01/2018 - 01/2006
4	Rett Syndrome (Rett's Disorder) 01/2022 - 01/2017
4	Obesity 10/2019 - 08/2010
4	Pain (Aches) 05/2019 - 07/2005
4	Psychotic Disorders (Schizoaffective Disorder) 10/2018 - 06/2014
4	Autistic Disorder (Autism) 01/2018 - 09/2012
4	Fragile X Syndrome (Martin Bell Syndrome) 01/2016 - 09/2012
4	Dyskinesias (Dyskinesia) 01/2016 - 08/2015
3	Dystonia (Limb Dystonia) 11/2023 - 08/2009
3	Opioid-Related Disorders (Opiate Addiction) 01/2023 - 01/2019
3	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2022 - 05/2017
3	Dementia (Dementias) 11/2022 - 01/2013
3	Hypertension (High Blood Pressure) 01/2022 - 01/2013
3	Retinoblastoma (Glioblastoma, Retinal) 01/2022 - 01/2018
3	Central Nervous System Diseases (CNS Diseases) 08/2021 - 09/2013
3	Epilepsy (Aura) 01/2020 - 01/2013
3	Brain Diseases (Brain Disorder) 01/2018 - 01/2012
3	Neoplasm Metastasis (Metastasis) 01/2017 - 09/2010
3	Breast Neoplasms (Breast Cancer) 02/2011 - 05/2009
2	Pulmonary Arterial Hypertension 10/2023 - 01/2023
2	Cardiotoxicity 01/2023 - 11/2012
2	Neuroinflammatory Diseases 11/2022 - 05/2012
2	Memory Disorders (Memory Loss) 01/2022 - 09/2009
2	Alcoholism (Alcohol Abuse) 12/2020 - 01/2020
2	Anhedonia 01/2020 - 01/2019
2	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2019 - 03/2015
2	Carcinoma (Carcinomatosis) 11/2017 - 01/2017
2	Cocaine-Related Disorders (Cocaine Addiction) 03/2016 - 08/2013
2	Bipolar Disorder (Manic Depressive Psychosis) 11/2015 - 01/2015
2	Type 2 Diabetes Mellitus (MODY) 11/2015 - 07/2014
2	Cardiovascular Diseases (Cardiovascular Disease) 11/2015 - 12/2013
2	Leukemia 07/2015 - 02/2014
2	Human Influenza (Influenza) 12/2014 - 09/2014

Drug/Important Bio-Agent (IBA)

30	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 01/2023 - 10/2008
20	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 01/2021 - 07/2005
11	Haloperidol (Haldol)FDA LinkGeneric 01/2021 - 11/2008
10	Cholinergic Agents (Cholinergics)IBA 01/2023 - 05/2010
10	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2022 - 01/2006
9	Glutamic Acid (Glutamate)FDA Link 01/2019 - 01/2006
7	Antipsychotic Agents (Antipsychotics)IBA 12/2023 - 11/2004
7	Proteins (Proteins, Gene)FDA Link 11/2022 - 01/2007
7	Phospholipase DIBA 05/2017 - 02/2009
7	N-Methylaspartate (NMDA)IBA 01/2017 - 11/2004
6	metabotropic glutamate receptor 4IBA 01/2016 - 01/2009
6	1-dodecylpyridoxal (PLD)IBA 05/2015 - 09/2010
5	Muscarinic M4 ReceptorIBA 11/2023 - 11/2015
5	LigandsIBA 10/2023 - 01/2015
5	Dopamine (Intropin)FDA LinkGeneric 01/2023 - 01/2006
5	Metabotropic Glutamate 5 ReceptorIBA 03/2016 - 10/2013
5	Levodopa (L Dopa)FDA LinkGeneric 01/2016 - 02/2012
4	Phosphotransferases (Kinase)IBA 01/2020 - 12/2005
4	EnzymesIBA 12/2018 - 02/2015
4	Cadherins (E-Cadherin)IBA 01/2017 - 05/2011
4	Glutamate Receptors (Glutamate Receptor)IBA 12/2016 - 05/2012
3	metabotropic glutamate receptor 3 (mGluR3)IBA 12/2023 - 01/2009
3	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2023 - 01/2020
3	Opioid Analgesics (Opioids)IBA 01/2023 - 01/2019
3	Muscarinic M1 ReceptorIBA 11/2022 - 10/2017
3	gamma-Aminobutyric Acid (GABA)IBA 01/2022 - 08/2015
3	Melphalan (Alkeran)FDA LinkGeneric 01/2022 - 01/2018
3	Retinaldehyde (Retinal)IBA 01/2022 - 01/2018
3	Dizocilpine Maleate (Dizocilpine)IBA 01/2022 - 03/2016
3	metabotropic glutamate receptor 7IBA 01/2021 - 01/2018
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021 - 01/2013
3	Clozapine (Clozaril)FDA LinkGeneric 01/2018 - 07/2013
3	Phosphatidic Acids (Phosphatidic Acid)IBA 05/2015 - 02/2011
2	KATP ChannelsIBA 02/2024 - 01/2019
2	Serotonin ReceptorsIBA 01/2023 - 01/2023
2	Antidepressive Agents (Antidepressants)IBA 01/2023 - 01/2020
2	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2022 - 11/2021
2	PotassiumIBA 01/2022 - 01/2011
2	Neurotransmitter Agents (Neurotransmitter)IBA 08/2021 - 03/2015
2	Baclofen FDA LinkGeneric 01/2020 - 01/2019
2	SterolsIBA 12/2018 - 12/2018
2	benzocycloheptapyridineIBA 01/2018 - 01/2013
2	Serotonin (5 Hydroxytryptamine)IBA 01/2018 - 03/2015
2	metabotropic glutamate receptor 2IBA 01/2018 - 01/2009
2	RNA (Ribonucleic Acid)IBA 01/2018 - 09/2009
2	Caspase 3 (Caspase-3)IBA 01/2018 - 02/2005
2	IsoxazolesIBA 11/2017 - 10/2017
2	LipidsIBA 05/2017 - 05/2015
2	Antiviral Agents (Antivirals)IBA 05/2017 - 12/2014
2	IsoenzymesIBA 05/2017 - 02/2005
2	xanomelineIBA 01/2017 - 05/2010
2	N-(3-chlorophenyl)picolinamideIBA 08/2015 - 02/2012
2	Amphetamine (Amfetamine)FDA LinkGeneric 03/2015 - 07/2014
2	Peptides (Polypeptides)IBA 01/2015 - 07/2014
2	Exenatide (Byetta)FDA Link 12/2014 - 07/2014

Therapy/Procedure

24	Therapeutics 02/2024 - 11/2005
5	Drug Therapy (Chemotherapy) 11/2021 - 01/2005